I have only worked NYCC once and it was in 2014 so my review may be a little different than others.
It was a struggle to get there and to afford everything for getting there but it sure was worth it. This hands down was my most profitable show ever and still is to this day 5/9/16 so that should say something. The artist alley there is incredible. The artist alley itself is in an off set part of the convention hall in Javits. It really is its own hallway/wing of artists and there are something between 400-500 of them there. Again, since this is a ReedPop run show they are all "flat" artists and the alley was juried so there are really no crafters or other types of artistic vendors in the alley. They are all on the main floor in Small Press or exhibitor booths and those too are great places to be. While the table and the trip may end up having cost an arm and a leg, you get an arm, a leg, and the rest of the body back and then some. Sorry for the sick humor but in other words you make a lot of money and some great connections there. NYCC sells out as well so attendance is huge! There are events leading up to the show called "Super week" that you can also participate in and that can add to the social momentum of your art at the con. While I did not work the show last year as I never got off the waitlist it will not deter me from trying again this year. It is 100% a worthwile show and now rivals that in attendance and sheer awesomeness of SDCC.